“It is your reaction to an adversity not the adversity itself that determines how your life’s story develops.” Dieter Uchtdorf WHY? What are the Underpinnings of Disease? What have we really learned over the last one to two hundred years of medicine? We left an era where infections killed the majority of children and adults, especially during childbirth and the first 5 years of life. Science gave us antimicrobial medicines and vaccines that altered this landscape and humans began to live decades longer. Medicine had conquered disease. However, it was not so. Insidiously, these victories were met with new problems called diseases of aging - heart disease, asthma, autoimmunity, diabetes, cancer, obesity, dementia and others...... and a literature review. Enjoy, Dr. M