Starting a story at the beginning makes sense… but what if there is a mistake in that first sentence? Does it invalidate the rest of the story? What if your experiment is based on an assumption that later turns out to be false? And how can you protect your tower of discoveries from tumbling down? We start with an unbelievable story about New York City being buried in horse manure, and discover the solution is in Detroit. Then we witness how British doctors thought they had solved polio, but actually hadn’t. Finally Dr Wayne Lautt explains Looping Theory… and how that can mistake proof your experimental results. These science stories from history shed light on the modern research being done on Type 2 Diabetes. Specifically, we highlight the work of SciMar as they examine the hormone HISS - Hepatic Insulin Sensitizing Substance - and the effect it has on glucose levels in people who are insulin resistant. www.SciMar.ca