Between 2019 and 2021, pediatric mortality rates had the largest increases in at least half a century. Steven H. Woolf, MD, MPH, of Virginia Commonwealth University Center on Society and Health, joins JAMA Associate Editor Tracy A. Lieu, MD, MPH, to discuss how racial and ethnic disparities and specific causes have factored into these increases and what this means for policymakers and clinicians. Related Content: Racial and Ethnic Disparities in All-Cause and Cause-Specific Mortality Among US YouthInjury Prevention Science and Firearm Injury in Pediatric Health

When initial treatment with varenicline or nicotine replacement doesn't work, does increasing dosage improve smoking cessation rates? Paul Cinciripini, PhD, of MD Anderson Cancer Center's Department of Behavioral Science, joins JAMA Executive Editor Gregory Curfman, MD, to discuss guidance on the best strategies for smoking cessation following an initial quit attempt. Related Content: Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement

Extensive evidence documents health disparities for lesbian, gay, and bisexual (LGB) women, including worse physical, mental, and behavioral health than heterosexual women. Sarah McKetta, ScM, MD, PhD, discusses these factors and their link to premature mortality with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content: Disparities in Mortality by Sexual Orientation in a Large, Prospective Cohort of Female Nurses

Can real-time EHR–generated recommendations safely reduce antibiotic use in hospitalized patients with pneumonia or UTI? Shruti K. Gohil, MD, MPH, of the University of California-Irvine, joins JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the INSPIRE randomized clinical trial. Related Content: Stewardship Prompts to Improve Antibiotic Selection for PneumoniaStewardship Prompts to Improve Antibiotic Selection for Urinary Tract InfectionHarnessing the Electronic Health Record to Improve Empiric Antibiotic Prescribing

Climate action is an urgent public health imperative. Climate change is causing excess morbidity and mortality and posing an increasing threat to mental health and well-being. The US health care sector is a significant contributor to this problem. A. Eugene Washington, MD, of Duke University, discusses accelerating climate action with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Accelerating Climate Action Through Academic Health Systems

The utility of prostate-specific antigen (PSA) screening for prostate cancer detection is impacted by detection of cancers with low risk of mortality. Editorialist Jeffrey J. Tosoian, MD, MPH, discusses a pragmatic approach to prostate cancer screening with JAMA Deputy Editor Mary L. (Nora) Disis, MD. Related Content: A Pragmatic Approach to Prostate Cancer ScreeningProstate Cancer Screening With PSA, Kallikrein Panel, and MRIProstate-Specific Antigen Screening and 15-Year Prostate Cancer Mortality

Infections due to multidrug-resistant organisms (MDROs) are difficult to treat with increased morbidity, mortality, length of hospitalization, and health care costs. Author Susan S. Huang, MD, MPH, from the University of California Irvine School of Medicine, joins JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss a new study that used a regional intervention to prevent MDROs. Related Content: Reducing Hospitalizations and Multidrug-Resistant Organisms via Regional Decolonization in Hospitals and Nursing Homes

The US Supreme Court will soon decide a case challenging the US Food and Drug Administration’s (FDA’s) approval of mifepristone. Author Holly Fernandez Lynch, JD, MBE, University of Pennsylvania, joins JAMA Executive Editor Gregory Curfman, MD, to discuss the science and politics surrounding this significant case. Related Content: The FDA in the Crosshairs—Science, Politics, and AbortionProvision of Medications for Self-Managed Abortion Before and After the Dobbs v Jackson Women’s Health Organization DecisionUnderstanding the Impacts of the Supreme Court Case FDA v Alliance for Hippocratic Medicine

How did GPT-4 Vision, a model that can work with images and text as input, perform when answering clinical challenge questions from medical journals? Daniel Truhn, MD, MSc, of the University Hospital Aachen in Germany, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss this topic. Related Content: Comparative Analysis of Multimodal Large Language Model Performance on Clinical Vignette Questions

An observational study by Lin Li, PhD, and colleagues, published in JAMA, found that pharmacotherapy was associated with reduced mortality in individuals with ADHD. Frances R. Levin, MD, of the Columbia Vagelos College of Physicians and Surgeons, who wrote an accompanying editorial, joins JAMA Associate Editor Donald C. Goff, MD, to discuss the results of this article. Related Content: Treating Attention-Deficit/Hyperactivity Disorder Matters

Introducing JAMA's new Communicating Medicine series, JAMA Associate Editor Anne Cappola, MD, ScM, discusses strategies for delivering effective messages in the patient encounter with authors Joseph Cappella, PhD, of the University of Pennsylvania, and Richard Street, PhD, of Texas A&M University and Baylor College of Medicine. Related Content: Delivering Effective Messages in the Patient-Clinician Encounter

How will new study results inform HIV prevention in the US and globally? JAMA Deputy Editor Preeti Malani, MD, MSJ, and author Jeanne Marrazzo, MD, MPH, director of NIAID, discuss these study findings and more. Related Content: HIV Preexposure Prophylaxis With Emtricitabine and Tenofovir Disoproxil Fumarate Among Cisgender Women

JAMA Associate Editor Romain Pirracchio, MD, MPH, discusses context and implications of the new pediatric sepsis criteria with authors Hallie Prescott, MD, MSc, of the University of Michigan and Ann Arbor VA Hospital, and Roberto Jabornisky, MD, of Northeastern National Medical School in Argentina. Related Content: Context and Implications of the New Pediatric Sepsis CriteriaTransitioning From SIRS to Phoenix With the Updated Pediatric Sepsis Criteria—The Difficult Task of Simplifying the Complex

Renters who received eviction filings experienced excess mortality associated with the COVID-19 pandemic. JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, discusses a recent study that underscores the importance of studying health outcomes among marginalized populations with author Nick Graetz, PhD, from Princeton University. Related Content: Examining Excess Mortality Associated With the COVID-19 Pandemic for Renters Threatened With Eviction

Childhood death rates remain high in some areas of sub-Saharan Africa, despite global reductions in childhood mortality. JAMA Deputy Editor Preeti Malani, MD, MSJ, and author Thomas Lietman, MD, University of California, San Francisco, discuss twice-yearly azithromycin to reduce childhood mortality. Related Content: Mass Azithromycin Distribution to Prevent Child Mortality in Burkina Faso

Bivalent mRNA COVID-19 vaccines were recommended for children and adolescents aged 5 to 17 years in the US, but were they effective? JAMA Associate Editor Tracy A. Lieu, MD, MPH, spoke with author Leora R. Feldstein, PhD, US Centers for Disease Control and Prevention, about the effectiveness of bivalent COVID-19 vaccines in children and adolescents. Related Content: Effectiveness of Bivalent mRNA COVID-19 Vaccines in Preventing SARS-CoV-2 Infection in Children and Adolescents Aged 5 to 17 Years

Following the Dobbs decision, females aged 18-45 years living in states with “trigger laws” that restricted access to abortion reported a greater increase in symptoms of anxiety and depression than those in states without trigger laws. JAMA Associate Editor Donald Goff, MD, speaks with editorialist Julia Steinberg, PhD, associate professor at the School of Public Health at the University of Maryland, about this topic. Related Content: Mental Health Symptoms When Abortion Access Is RestrictedAnxiety and Depression Symptoms After the Dobbs Abortion Decision

JAMA Deputy Editor Preeti Malani, MD, MSJ, and author Alexander K. Smith, MD, MS, MPH, University of California, San Francisco, discuss the importance of 2 new palliative care trials that were recently published in JAMA. Related Content: A Tale of 2 Palliative Care TrialsAssociation of Receipt of Palliative Care Interventions With Health Care Use, Quality of Life, and Symptom Burden Among Adults With Chronic Noncancer Illness

Dialysis facilities in the US are financially rewarded for higher rates of home dialysis and kidney transplant, but facilities that serve patients with high social risk might have a harder time meeting these goals. JAMA Associate Editor Karen E. Joynt Maddox, MD, MPH, speaks with Amal N. Trivedi, MD, MPH, of Brown University, about how this plays out under the ESRD Treatment Choices Model. Related Content: Social Risk and Dialysis Facility Performance in the First Year of the ESRD Treatment Choices Model

Alpha-gal syndrome is a food allergy to red meat products that develops after affected individuals are bitten by a tick. JAMA Deputy Editor Kristin Walter, MD, MS, discusses alpha-gal syndrome with author Mariel R. Benjamin, MD, assistant professor in the Division of Allergy and Clinical Immunology at Michigan Medicine. Related Content: What Is Alpha-Gal Syndrome?