The story of leptospirosis is chock full of variety. In terms of biology, any number of different Leptospira species and serovars can play a role in infection, and the resulting infection can run from asymptomatic to deadly. As for ecology, virtually any mammalian species can either act as an affected reservoir for the pathogens or fall victim to a deadly infection. The history of leptospirosis takes us across continents and through centuries, illustrating how changes in scientific thought and technology shaped our understanding of this and other zoonotic diseases. And the current status of this One Health disease is no less varied, both in the wide distribution of leptospirosis as well as the vastly differing (but disturbingly high) estimates of annual cases and deaths. In this episode, we do our best to tackle as much of the variety in this neglected disease as we can, from its impact on us and our furry friends, to the classic story of its discovery and the biggest remaining gaps in our knowledge today. Tune in for all this and more!